(+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor

J Med Chem. 1993 Jun 25;36(13):1918-9. doi: 10.1021/jm00065a015.

Authors

F D King¹, A M Brown, L M Gaster, A J Kaumann, A D Medhurst, S G Parker, A A Parsons, T L Patch, P Raval

Affiliation

¹ SmithKline Beecham Pharmaceuticals, Department of Medicinal Chemistry, Harlow, Essex, U.K.

PMID: 8515429
DOI: 10.1021/jm00065a015

No abstract available

MeSH terms

Animals
Brain / metabolism
Carbazoles / chemical synthesis*
Carbazoles / metabolism
Carbazoles / pharmacology*
Dogs
In Vitro Techniques
Molecular Conformation
Rabbits
Rats
Receptors, Serotonin / classification
Receptors, Serotonin / metabolism*
Serotonin Receptor Agonists / chemical synthesis*
Serotonin Receptor Agonists / metabolism
Serotonin Receptor Agonists / pharmacology*
Swine
Vasoconstriction / drug effects

Substances

Carbazoles
Receptors, Serotonin
Serotonin Receptor Agonists
3-amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole